We focused on 3,701 GC events delimited by five-hundred bp or less (GC500 sequences). Presence indicates the total number of motifs per 100 GC500 sequences, including the possible multiple presence in a single sequence. For display purposes, sequence motifs are chosen between forward and reverse to maximize the presence of A and/or C nucleotides.
Prior analyses inside the D. pseuddobscura known a notably confident correlation ranging from recombination rates and easy repeats, additionally the design CACAC , CCTCCCT and you may CCCCACCCC . An equivalent investigation during the D. persimilis discover a positive organization out of speed on CCNCCNTNNCCNC sequence motif regarded as associated with the person recombination pricing . A newer study reported the motif GTGGAAA as introduce close occurrences during the D. melanogaster . The research confirms the important enrichment of some of these sequences ( CACAC and you can CCTCCCT ) and you can finds brand new ones, since there is zero service for CCCCACCCC or GTGGAAA because themes on the enhanced recombination inside D. melanogaster.
In mammals, new histone methyltransferase PRDM9 objectives the 13-mer CCNCCNTNNCCNC theme demonstrated significantly more than through the zinc-little finger selection , , hence motif is actually of the crossover interest when you look at the 41% from people hotspots . Nothing of your own motifs recognized within our analysis having either-or GC is actually otherwise has got the complete 13-mer PRDM9 motif. I perform observe although not less models of this 13-mer within this several different design out-of (M4 and you will M16 into the Profile six). Motif M4 provides the 7-nucleotide theme CCTCCCT very first for the spot devotion during the people , if you are motif M16 contains a ten-mer series ( CCNTCGCCGC ) that overlaps into extended PRDM9 theme. Continue reading “versus GC landscapes along side genome”